The future of
single-domain antibodies

Meet Etienne at the BSCB/BSDB 2017 annual meeting 2-5 April, Warwick, UK Read more
Meet us for the 20th edition of the worm meeting: VerMidi XX. 20 January, Lyon, France Read more
Wishing you lots of happiness and success! January, Paris, France Read more
The 2016 meeting of the GDR3545 RCPG-Physiomed will be held in Tours, from 22nd to 25th of November. 22-25 November, Tours, France Read more
Thank you to all our attendees for coming to our event October, Paris, France Read more

Validated antibodies for all IF applications

Anti-tubulin VHH from hs2dAb library labelled with Cy5. Nucleus are stained with DAPI

Identification of intracellular antibodies

Anti-p53 VHH fused with mCherry colocalizes with full length GFP-p53 in SKBR3 cell line
We asked Hybrigenics to select intrabodies against four different proteins involved in vesicular trafficking. They quickly provided us with several candidates per protein, in the form of ready-to-u… Dr Thierry Galli (Jacques Monod Institute, France)
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As part of a collaboration under FP7-HEALTH AgedBrainSYSBio program, Hybrigenics selected and validated anti-Fyn VHH intrabodies. Our lab currently explores these very exciting novel tools in prima… Prof. Michel Simmoneau (Centre for Psychiatry and Neuroscience, France)
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We received many VHHs from Hybrigenics selected and validated against Tau and phosho-Tau. The biochemical and functional characterization of those binders is ongoing but we can already say that thi… Dr Luc Buée (Jean-Pierre Aubert Research Centre, France)
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Hybrigenics Single-Domain Antibodies

Hybribody is an integrated solution for custom recombinant antibody selection and validation. Hybrigenics Services offers to screen its unique Humanized Synthetic Single Domain Antibodies (hs2dAb) library for the in vitro selection of stable ,15 kDa llama VHH recognizing specifically your native and unprocessed antigen, with no need to immunize animals. We deliver validated antibodies verified for the application you require i.e ELISA or Immunofluorescence . Hybrigenics’ expertise in Yeast Two-Hybrid coupled with a specific Phage Display technology allows selecting antibodies validated for intracellular applications such as live cell imaging or target knock-down (so-called "Intrabodies"). We offer a specific Phage Display selection for cell surface antigens like GPCRs.

With Hybribody, you get the cDNA clone of your antibody and can produce it as you need in bacteria, with no batch to batch variability. Hybrigenics also transforms your favorite VHH into a multispecies "Minibody" for all your cellular experiments, by fusion to Fc fragments from human, mouse, rabbit or goat.

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