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- Synthetic VHH Library
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Hybrigenics offers a wide range of services for custom antibody selection and validation. We provide researchers with customized antibody screening services using a unique Humanized Synthetic Single Domain Antibody (hs2dAb) library coding 3.109 llama VHHs. It allows for the in vitro selection of very stable, small (15 kDa) and specific VHH recognizing your native antigen of interest, without the need to immunize animals.
Combining our Antibody Phage Display protocol using non-adsorbed antigen with our Yeast Two-Hybrid screening process, we can even select Intrabodies validated for intracellular applications such as live cell imaging.
Our in vitro selection enables direct access to the sequence of your selected VHHs. An array of multi-species Fc’s can be easily fused to the VHH of interest, resulting in a fully functional recombinant single-chain antibody or “Minibody” for all your cellular studies. We also offer a specific Phage Display selection on live cells and FACS validation for cell surface antigens like GPCR's.