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Learn more about our synthetic VHH applications.

This article published on October 2017 in eLIFE by our colleagues Aurélien Roux, Franck Perez, Sandrine Moutel and their team, shows how the use of a specific VHH selected from our synthetic library, allowed to understand better the dynamin-mediated membrane fission mechanism by following the dynamin’s GTPase activity in real time in cells.

Read the article: Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

 Average images of time-lapse movies of dynamin triple knockout cells (TKO) expressing dyn1/2-mCherry and dynab-EGFP. Scale bar 10 µm.

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